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Concentric OFM Probe Kit for Brain

Cerebral open flow microperfusion (cOFM) is a membrane-free sampling technique for long-term sampling of cerebral interstitial fluid (cISF).  Standard cOFM probes kits are composed of a guide, healing dummy, sampling insert and locking wedge. 

  • Standard sizes include 7mm, 8mm, 9mm, 10mm
  • Recommended for use with mice or rats
  • Gamma-irradiated (sterile)
  • Custom probes available, click here.

 

Cerebral open flow microperfusion (cOFM) is a membrane-free sampling technique for long term sampling of cerebral interstitial fluid and cerebrospinal fluid. Macroscopic openings in the cOFM probe avoid membrane-related problems such as biofouling, protein clotting, high molecular weight cut-off and the exclusion of large and lipophilic substances. cOFM is thus uniquely suited for unlimited monitoring of any substance in the cerebral interstitial fluid. cOFM probes are designed to elicit minimal tissue reaction and reestablishment of the blood brain barrier within 14 days after implantation along with the following:

  • Probes are membrane free push-pull type probes with macroscopic openings
  • Allows sampling of Peptides, Proteins, Antibodies, Lipophilic Substances, Bound and Unbound Drugs, Enzymes, Nanocarriers, Vesicles and Cells
  • Allows sampling of drugs and endogenous substances in brain tissue with an intact BBB.
  • Allows continuous monitoring of drug transport across the intact BBB.
  • Allows long-term monitoring for up to 30 days

 

Concentric OFM Probe Kit for Brain

Item Number Item Description Illustration / Specifications

cOFM-P-6-1

Recommended for:
Mouse dorsal regions
Mouse ventral regions
Rat dorsal regions

Concentric OFM Probe Kit for Brain
(6 mm shaft, 1 mm open surface, 7 mm total length)
(pack of 3)

Each pack includes:
1 pc. cOFM guide (X=6 mm, Y=1 mm)
1 pc. cOFM healing dummy cOFM-D-7 (Z=7 mm)
1 pc. cOFM sampling insert  cOFM-S-7 (Z=7 mm)
2 pc. cOFM locking wedge cOFM-Lock

 

 Click here for probe implant illustration

 cOFM-P-6-2

Recommended for:
Mouse dorsal regions
Mouse ventral regions
Rat dorsal regions

Concentric OFM Probe Kit for Brain
(6 mm shaft, 2 mm open surface, 8 mm total length)
(pack of 3)

Each pack includes: 
1 pc. cOFM guide (X=6 mm, Y=2 mm)
1 pc. cOFM healing dummy cOFM-D-8 (Z=8 mm)
1 pc. cOFM sampling insert  cOFM-S-8 (Z=8 mm)
2 pc. cOFM locking wedge cOFM-Lock

 cOFM-P-8-1

Recommended for:
Rat ventral regions

Concentric OFM Probe Kit for Brain
(8 mm shaft, 1 mm open surface, 9 mm total length)
(pack of 3)

Each pack includes: 
1 pc. cOFM guide (X=8 mm, Y=1 mm)
1 pc. cOFM healing dummy cOFM-D-9 (Z=9 mm)
1 pc. cOFM sampling insert  cOFM-S-9 (Z=9 mm)
2 pc. cOFM locking wedge cOFM-Lock

cOFM-P-8-2

Recommended for:
Rat ventral regions

 Concentric OFM Probe Kit for Brain
(8 mm shaft, 2 mm open surface, 10 mm total length)
(pack of 3)

Each pack includes:
1 pc. cOFM guide (X=8 mm, Y=2 mm)
1 pc. cOFM healing dummy cOFM-D-10 (Z=10 mm)
1 pc. cOFM sampling insert  cOFM-S-10 (Z=10 mm)
2 pc. cOFM locking wedge cOFM-Lock

 

cOFM probes have four components:  guide, healing dummy, sampling insert and locking wedge. 

Please refer to the schematic below when selecting the cOFM probe.

The notation of the product numbers refers to the length of the guide, open surface and healing dummy or sampling insert. 

For example:  cOFM-P-6-1; X=6, Y=1, Z=7.  Individual replacement components for this cOFM probe kit would be ordered as:  cOFM-GD-6-1, cOFM-D-7 and cOFM-S-7

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