ISF Sampling in Dermal and Adipose Tissue - dOFM and aOFM
a/d OFM platform has been extensively employed in clinical setting to advance drug development and understanding the general physiology and pathophysiology. a/d OFM can continuously and repeatedly assess bioavailability of drug in the dermis and adipose tissue.
dOFM – dermal OFM
- Linear push-pull type probes that are membrane free wih macroscopic openings
- Used for sampling of Peptides, Proteins, Antibodies, Lipophilic Substances, Bound and Unbound Drugs, Transporters, Enzymes, Nanocarriers, Vesicles and Cells
- Concentrations and action of dermatological drugs (PK/PD) are measured directly in the dermis.
- Transport and effects of drugs are monitored after topical or systemic application (e.g., topical glucocorticoids and systemic antibodies in psoriatic or inflammatory animal models).
aOFM – adipose OFM
- Concentrations and action of drugs (PK/PD) are measured directly in adipose tissue.
- Independent of the mode of administration (oral, subcutaneous, topical, intravenous or other).
- Can be combined with glucose-clamp techniques to investigate e.g. insulin sensitivity as well as insulin concentrations and the effects in subcutaneous tissue.
- All a/dOFM supplies are gamma-irradiated (sterilized)
Standard a/d OFM Probe
| Item Number | Item Description | Specifications |
| a/d-OFM-P-15 | Linear OFM Probe |
Inert & low adsortive polymer, outer diameter 0.55 mm; inner diameter 0.40 mm, exchange area 15 mm |
| a/d/-OFM-P-05 | Linear OFM Probe | 5 mm exchange area |
| a/d/-OFM-P-02 | Linear OFM Probe | 2 mm exchange area |
a/d linear OFM probes are made of inert & low adsorptive polymer.
Outer diameter 0.55 mm
Inner diameter 0.40 mm
Shaft length: 200 mm
Exchange area: 15mm
Please refer below for a schematic of the a/dOFM linear probe.
