No study of pharmacokinetics, drug delivery, metabolism, or toxicity is complete without a determination of the drug concentration in blood. The Culex® Automated Blood Sampler is the ideal way to serially sample blood from species ranging from mice to pigs. However, if your needs are less frequent or less rigorous, the BASi® IV microdialysis probe is a comparatively simple way to look at microdialysis based relative changes in blood analyte concentrations.
IV Vascular Microdialysis Probes were designed for implantation into a rat size jugular vein. They are also suitable for other soft tissues. Each microdialysis probe includes an implantation needle and temporary cannula (split introducer) which aid placement. As illustrated in the drawing above, the thin-walled, plastic introducer slides over the implantation needle, this is then used to pierce the vein. The needle is removed and replaced with an IV probe. Flexible wire mesh on the probe is sutured to the pectoral muscle. The cannula is then split and pulled out of the vein, leaving the microdialysis probe inserted. Inlet and outlet lines to the probe are housed within a single piece of flexible tubing, which is externalized by use of a tubing introducer trocar (MR-5313). The small OD of the flexible probe is less likely to occlude the blood vessel.
IV microdialysis probes are suitable for use in freely moving animals.
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