Novel In Vivo Approaches for Integrative Pharmacology and Toxicology Studies: Combining Radio Telemetry with Automated Sampling/Delivery Systems
Stress and PK: The Influence of Blood Sampling Method on Pharmacokinetics in the Rat
Culex DBS: Automated Dried Blood Spot Collection
Pharmacokinetics on mouse using an automated blood sampler Culex. Bertin Pharma’ tools used to improve the technical approach
Application of Culex Sampling in Mice and Dried Blood Spot Technique Using LC-MS/MS for Pharmacokinetic Studies
Assessment of the Culex-L/PigTurn for Mimicking Human Biopharmaceutical Relevancy Utilizing the Porcine Model
Case Studies Using Culex & Telemetry Technologies
Manual vs. Culex PK in the Rat and Mouse
The History of Automatic Blood Sampling at BAS.
An Automated Blood Sampler for Pharmacokinetic and Pharmacodynamic Studies.
Culex ABS Part I: Introduction to Automated Blood Sampling.
Culex ABS Part II: Managing Freely Moving Animals and Monitoring their Activity.
A Novel Approach to Combining Automated Sample Collection, Extraction and Analysis to Obtain PK/PD Information for Preclinical Studies.
Automated Blood Sampler for Preclinical R&D. P.T. Kissinger. Genetic Engineering News, 2001, 21:18. (print only)
A Preliminary Study on the Feasibility of an Automated Blood-Sampling System in Conjunction with Liquid Chromatography/Mass Spectrometry. H. He, R. Kramp, L. Ramos, and R. Bakhtiar. Rapid Commun. in Mass Spectrom., 2001, 15, 1768-1772. (print only)
Automated Dosing and Sampling System Coupled to LC/MS/MS for the Determination of Endogenous Steroids and DMPK Study
Clozapine Distribution in Rat Brain and Lung: A Comparison of Imaging by DESI-MS vs. LC-MS/MS Analysis of Homogenates
LC/H-ESI MS/MS and Higher Mass Resolution for Quantitative Assay and PK and PD Study Using Automated Blood Sampling Systems
Good Preclinical Bioanalytical Chemistry Requires Proper Sampling from Laboratory Animals: Automation of Blood and Microdialysis Sampling Improves the Productivity of LC/MSMS.
Automated Blood Sampling From Awake Laboratory Animals Coupled to 96-Well Sample Preparation Tools and LC/MSMS Improves Data Quality, Enhances Efficiency and Facilitates Parallel Measurements of Behavior and Physiological Parameters
Determination of (-)-Epigallocatechin Gallate in Rat Blood Liquid Chromatography with Multi- Channel Electrochemical Detection and Automated Blood Sampler.
Liquid Chromatography with Multi-Channel Electrochemical Detection for the Determination of (-)- Epigallocatechin Gallate in Rat Blood Utilizing an Automated Blood Sampler.
Liquid Chromatography / Tandem Mass Spectrometry for the Determination of Carbamazepine and Its Metabolite in Rat Blood Collected by an Automated Blood Sampling System.
BASi Application Capsule 371: Determination of Naringenin in Rat Plasma with the Culex Automated Blood Sampler Coupled with LCEC
Liquid Chromatography with Multi-Channel Electrochemical Determination of trans-resveratrol in Rat Blood Sampled by Automated Blood Sampling System. Y. Zhu, T. Huang, M. Cregor, H.Long, C.B. Kissinger, P.T. Kissinger J. of Chromatography B, 2000, 740, 129-133. (print only)
Liquid Chromatography with Multi-Channel Electrochemical Determination of Daidzen in Rat Blood Sampled by an Automated Blood Sampling System. F. Tian Y. Zhu, H.Long, M. Cregor, F. Xie, C.B. Kissinger, P.T. Kissinger J. of Chromatography B, 2002. In press. (print only)
Blood Sampling Method Influences Pharmacokinetics in the Rat
Discovery Rat Pharmacokinetic Applications Using the Culex Automated Blood Sampler
Continuous Monitoring of Corticosterone in Conscious and Freely-Moving Rats for Anxiolytic Drug Screening
Application Of An Automated Blood Sampling Method To Pharmacokinetic Studies In Rodents In Drug Discovery.
Pharmacokinetic and Pharmacodynamic Studies in Rats Using a New Method of Automated Blood Sampling.
Influence of Blood Sampling Method on Biometric and Chemical Markers of Stress in the Rat.
Application of the Culex Automated Blood Sampler in the Pharmacokinetic Study of SU6668 in Awake Rats.
Automating in vivo PK Analysis.
Effects of Blood Sampling Technique on Pharmacokinetics.
Demonstration of the relationship between in vivo dopamine efflux, behaviour and drug pharmacokinetics
Experiences with Automated Blood Sampling from Freely Moving Rats for PK/PD Screening.
Automating Oral Dosing for PK/PD Applications
Comparison of Automated and Manual Oral Dosing on the Absorption, Conversion, and Locomotor Activating Effects of Nicotine. J.E. Woods II, C. P. Gunaratna, R. R. Guinn, B.P. Solomon, C.T. Duda and C.B. Kissinger. Current Separations
Semi-mechanistic Pharmacokinetic/Pharmacodynamic Modelling of the Antinociceptive Response in the Presence of Competitive Antagonism: The Interaction Between Tramadol and its Active Metabolite on m-Opiod Agonism and Monoamine Reuptake Inhibition in the Rat. H. Beier, M. J. Garrido, T. Christoph, D. Kasel, and I.F. Troconiz. Pharmaceutical Research, 2007, in press.
Use of trifluoroacetic acid to quantify small, polar compounds in rat plasma during discovery-phase pharmacokinetic evaluation. Journal of Chromatography B 856: 165-170.
Combinatorial Pharmacology in Mice: Integration of Brain Microdialysis and Automated Blood Collection in a Single Subject
Elimination Of Interanimal Differences By Using A Single Mouse For The Entire PK/PD Study
Oral and Intravenous Dosing in Combination with Automated Blood Sampling for a Complete Bioavailability Profile in Mice
Operational Validation of the Culex-L Automated Blood Collector For Use in a Non-human Primate
Prototype Device for Computerized Blood Sampling and Data Collection in Freely Moving Swine
ECG and Pharmacokinetic Assessment in the Freely Moving Pig
Measuring Induction of Carbamazepine Metabolism in Pigs Using Automated Blood Sampling
Blood-Brain Barrier or Blood-Brain Turnstile? Use of non-radiolabeled 4-TAA as a marker of blood-brain barrier integrity.
Use of the Culex Bambino to Measure Brain Neurotransmitters, Plasma Corticosterone and Drug Levels with Behaviour in the Same Freely-Moving Rat
An automated blood sampler for simultaneous sampling of systemic blood and brain microdialysates for drug absorption, distribution, metabolism, and elimination studies
Steady-State Brain Concentrations of Antihistamines in Rats. Pharmacology, 72(2): 92-98
Peritoneal Microdialysis with Simultaneous Venous Blood Sampling: Insights into Pharmacokinetics of Free vs. Total Drug in Rodents
Online Monitoring of Hydrogen Peroxide in Freely-Moving Rodents
Monitoring Gamma-Aminobutyric Acid (GABA) in Rat Brain Extracellular Fluid: Analysis of Rat Brain Microdialysates with LCMSMS
Monitoring Free Drug in Lung Tissue with Concurrent Automated Blood Sampling in the Unrestrained Rat.
Peritoneal microdialysis in freely moving rodents: an alternative to blood sampling for pharmacokinetic studies in the rat and the mouse. European Journal of Pharmaceutical Sciences 30(1): 75-83.
Programmed Blood and Bile Collections from Freely-Moving Rats: A Study Tracking Nicotine and its Cotinine Metabolite
Measuring First-Pass Metabolism Using Automated Blood Sampling
A New Method for Determining Urine Frequency in Rats
Renal Function Evaluation in an Integrative Cardio-Renal Pharmacology Model using Culex Empis® Automated Drug Infusion System and Radio Telemetry
Multi-Compartmental PK-PD Modeling of Baclofen
Optimization of an In Vivo PK-PD Pharmacology Model
Comparison of Baseline Values of Rat Urinary Nephrotoxicity Biomarkers Using BASi Culex System vs. Metabolic Cages
The combination of DSI rat telemetry and the Culex Automated Blood Sampler (ABS) for multiparameter safety pharmacology screening.
Automated Blood Sampling with Concurrent Electrocardiograms for Laboratory Animals.
Evaluation of Rats for a New In Vivo Screening Model of Q-T Interval Prolongation by New Chemical Entities.
Use of Behavior as a Pharmacodynamic Parameter During Pharmacokinetics Studies on an Automated Blood Sampler
Monitoring Animal Activity during Automated Blood Sampling: An Early Warning System During First-Pass in Animal Drug Screening.
Continuous Collection of Saliva from an Untethered Human: Implications for Pharmacokinetics and Pharmacodynamics.
Evaluation of Post-Surgical Recovery for Rats in an Automated Blood Sampler vs. Rats Returned to a Home Cage.
Synaptic Activity Regulates Interstitial Fluid Amyloid-b Levels In Vivo. John R. Cirrito, Kelvin A. Yamada, Mary Beth Finn, Robert S. Sloviter, Kelly R. Bales, Patrick C. May, Darryle D. Schoepp, Steven M. Paul, Steven Mennerick, and David M. Holtzman. Neuron, Vol. 48, 913–922, December 22, 2005, Copyright ª2005 by Elsevier Inc. DOI 10.1016/j.neuron.2005.10.028 (print only)
Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-b In Vivo. John R. Cirrito, Jae-Eun Kang, Jiyeon Lee, Floy R. Stewart, Deborah K. Verges,1Luz M. Silverio, Guojun Bu, Steven Mennerick, and David M. Holtzman Neuron 58, 42–51, April 10, 2008 ª2008 Elsevier Inc. (print only)
Pharmacokinetics of green tea catechins in extract and sustained-release preparations. Journal of Dietary Supplements. 5(3): 248-263.
Toxicokinetics and Hydrolysis of Artelinate and Artesunate in Malaria-Infected Rats International Journal of Toxicology, 24 (4): 241-250.
The Evaluation of Radiolabeled Artesunate on Tissue Distribution in Rats and Protein Binding in Humans. Am. J. Trop. Med. Hyg., 75(5): 817-826
Pharmacokinetic evaluation of a 1,3-dicyclohexylurea nanosuspension formulation to support early efficacy assessment Nanoscale Research Letters, 2(6): 291-296.
A Nonspecific Phosphotyrosine Phosphatase Inhibitor, Bis(maltolato)oxovanadium(IV), Improves Glucose Tolerance and Prevents Diabetes in Zucker Diabetic Fatty Rats. Experimental Biology and Medicine 230:207-216.
Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. Journal of Pharmaceutical Sciences, 95(2): 256-267
Saturation of multidrug-resistant protein 2 (Mrp2/Abcc2)- mediated hepatobiliary secretion: nonlinear pharmacokinetics of a heterocyclic compound in rats after intravenous bolus administration. Drug Metabolism and Disposition 37: 841-846.
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