BASi Articles and Presentations
BASi scientists regularly participate in conferences and present updates on their research. We frequently receive requests
for reprints of these posters from participants at the conference. In the future, we will be directing these requests to this
portion of our web site, where copies of the text and data from such presentations will be posted for your convenience. We
welcome your feedback and invite you to request more information directly from the listed BASi scientist.
Pharm Analysis
A Team Approach in CRO for Effective Execution of Analytical Method Development and
Validation (63KB)
Jianming Lei and Maggie McClure Bioanalytical Systems, Inc.
Determination of an Acceptable Preservative for Use in Minocycline Solution
Extracts from Antibiotic Impregnated Medical Devices (512KB)
R. L. Steffen*, A. K. Wilson, D.G. Cuttell, M.S. Medrano, L.R. Brewster, BASi
A. Hoffa, Cook, Inc.
Method Development and Validation of an HPLC Assay for Choline in Carbachol
Formulations Using a Post Column Reactor and a Chemically Modified Glassy Carbon Electrode (67K)
R.L. Steffen, L. Liu, G. Chong, R. Frank, T. Gibson
Bioanalytical Chemistry
Evaluation of the Dried Blood Spot technique for the quantification of
diltiazem in human blood
Neil Doleman,
BASi, UK
Laser Diode Thermal Desorption (LDTD) an Alternative to the LC for High-Throughput Quantitation: Some Early Case Studies
Don Gray, Senior Scientist, BASi
Use Of Noise Parameters to Optimize Data Collection Rates in LC-MS
Michael S. Alexander, Melissa Keiser
BASi Northwest Laboratory, McMinnville, OR
Quantification of Oxycodone and Its Major Metabolites in Human Plasma by HPLC/MS/MS
Mary E. Leonard, Vance Cooper, Lori Payne
BASi Northwest Laboratory, McMinnville, OR
Bioanalysis of Ribavirin in Rat Plasma by High Pressure Liquid Chromatography – Tandem Mass Spectrometry (HPLC-MS/MS)
Lou Anne McKown, Lori Payne
BASi Northwest Laboratory, McMinnville, OR
Development and Validation of An LC-MS/MS Method for the Quantification of Rapamycin in Porcine Whole Blood and Tissues
Zahuindanda M. DeForrest*, Scott D. McConkie, Peter J. Mann, and Melissa M. Kiser
BASi Northwest Laboratory, McMinnville, OR
Method Development and Validation of Caffeine and Paraxanthine in Human Plasma
Rachel Sun, Orlando J. Bravo, Brian J. Engel
BASi, 2701 Kent Avenue, West Lafayette, IN 47906
Validation of Pioglitazone in Human Serum by Two Sample Introduction Methods: LDTD-APCI/MS/MS and LC-ESI/MS/MS
Michael Pugh, Don Gray, Rachel Sun, Brian J. Engel
BASi, 2701 Kent Avenue, West Lafayette, IN 47906
Mass Spectroscopy in the CRO World
Bernie Monaghan, James Hillis, Mark Wareing
Reprinted with permission from International Labmate
LC/MS/MS Bioanalysis of Acidic and Basic Compounds with Double Liquid-Liquid
Extraction by Changing pH in Between (113KB)
Rachel Sun, Gary Overdorf
Bioanalytical Systems, Inc., 2701 Kent Avenue, West Lafayette, IN 47906
Difficulties in Developing a Sensitive Assay for the Quantification of Rifampin
in Multiple Biological Matrices by LC-MS/MS (231KB)
Keith D. Zientek, Michael D. Nelson, and Lori Payne
Bioanalytical Systems, Inc. McMinnville, OR
Challenges in Developing a Highly Sensitive LC-MS/MS Method for the Quantification
of Rifampin (280KB)
Lori D. Payne, Keith D. Zientek, and Michael D. Nelson
Bioanalytical Systems, Inc. McMinnville, OR
Analytical Challenges in the Development of an Assay for Capecitabine and Three of
its Metabolites (216KB)
Lori D. Payne* and Ryan Morrison^
*Bioanalytical Systems, Inc., McMinnville, OR
^Pfizer Global Research & Development, Chesterfield, MO
Quantitative Analysis of Benzphetamine in Human Plasma using LC-MS/MS (93KB)
William G. Sawyers and Paul S. McCafferty
BASi – Clinical Research Unit, Baltimore, MD
Quantitative Determination of Delta-9-THC and 11-Hydroxy-Delta-9-THC in Human
Plasma Using LC-MS/MS (110KB)
Denise Townsend and William Sawyers
BASi – Clinical Research Unit, Baltimore, MD
Quantitative Analysis of Pilocarpine in Human Plasma using LC-MS/MS (97KB)
Iris Stadelmann and William Sawyers
BASi – Clinical Research Unit, Baltimore, MD
Is Your Paclitaxel Method HIV Positive? (86KB)
Lori D. Payne, Katie J. Amrhein, and Melissa M. Kiser
Bioanalytical Systems, Inc.
Determination of 5-Fluorouracil in Human Plasma Using LC-MS/MS (99KB)
Lori D. Payne, Michael D. Nelson, Michael S. Alexander, Ryan M. Minikis, and John W. Dolan
Bioanalytical Systems, Inc.
Validation Of An LC/MS/MS Assay For Tenofovir In Human Serum (83KB)
Sheela Das, Ph.D.
Liquid Chromatography / Tandem Mass Spectrometry for the Determination of
Carbamazepine and Its Metabolite in Rat Blood Collected by an Automated Blood Sampling System (125K)
Yongxin Zhu, Hwa Jiang, Rita Hilt, Phil Wong, Candice B. Kissinger, and Peter T. Kissinger
Determination of Antioxidants and Phenolic Constituents by Liquid Chromatography
with Multi-Channel Electrochemical Detection (77K)
Zhu Yongxin, Zhou J, Long H, Tian F, Janle E*, Kissinger P
Increased Sample Throughput For Ketoconazole Analysis By Automated 96-Well Sample
Preparation And Multiplexed HPLC (51K)
K. Szczap, C. Loop, D. Gray, H. Freiser, R. Shoup, A. Witkowski
Increased Assay Robustness and Throughput Using Automated 96-well Solid Phase
Extraction (98K)
S. Das, E. Fisher, T. Grever, and B. Burras
Determination of Isoflavones in Natural Sources and Biological Fluids (58K)
Feifei Tian, Yongxin Zhu, Hong Long, Fuming Xie, Meloney Cregor, Chester Duda, Elsa Janle and Peter Kissinger
Determination of (-)-Epigallocatechin Gallate in Rat Blood Liquid Chromatography
with Multi-Channel Electrochemical Detection and Automated Blood Sampler (33K)
Yongxin Zhu, Hong Long, M. Cregor, L. Coury, E. Janle, P.T. Kissinger
Determination of Amprenavir in Human Heparinized Plasma by LC/MS/MS (136K)
Ronald E. Shoup, Yingjie Deng, Angela P. Johnson, and David M. Morris
Liquid Chromatography with Multi-Channel Electrochemical Detection for the Determination of (-)-Epigallocatechin Gallate in
Rat Blood Utilizing an Automated Blood Sampler
Quantitation of Pamoic Acid in Human, Rat, and Canine Plasma (177K)
N. Simmons
Sciex API 3000 Versus Finnigan TSQ 7000: A Head to Head Comparison of Linearity
(132K)
A. Witkowski, C. Serpe, G. Baker, D. Gray, J. Burrows, K. Watson, J. Chiu
Does Your LC/MS/MS Data Look Better Than it Really Is? (588K)
S. Sitaraman, A. Witkowski, J. Plassard, B. Schrader, K. Szczap, and B. Beato
A Novel Approach to Combining Automated Sample Collection, Extraction and Analysis to Obtain PK/PD Information for
Preclinical Studies
Automation of Liquid-Liquid Extractions in a 96-Well Format Using the Packard
MultiPROBE ™ (154K)
S. Sitaraman, T. Grever, and R. Hurd
A Pre-Validation Strategy for Evaluating Bioanalytical Methods (124K)
J. Burrows, N. Shearsby, J. Chiu, K. Watson, A. Witkowski
Simultaneous Determination of Caffeine from Blood, Brain and Muscle Using Microdialysis in an Awake Rat and Effect of
Caffeine on Rat Activity
Comparison of Conventional Packed Bed, Extraction Disk, and 96-Well Solid Phase
Extraction Formats for the Determination of Methotrexate in Plasma
E. C. Hernandez, C. E. Serpe, and A. Witkowski
In Vivo and In Vitro Characterization of a Microdialysis Shunt Probe: Caffeine and Phenolphthalein Glucuronide as Model
Compounds
Electrochemical Determination of Lead(II) in Calcium Tablets
Husantha Jayaratna, M.B. Voelz, and C.S. Bruntlett
Automated Sampling from Large Animals
Contact BASi for access to a PDF of any of the following titles:
ECG and Pharmacokinetic Assessment in the Freely Moving Pig
Measuring Induction of Carbamazepine Metabolism in Pigs Using Automated Blood Sampling
Prototype Device for Computerized Blood Sampling and Data Collection in Freely Moving Swine
Automated Blood Sampling
Contact BASi for access to a PDF of any of the following titles:
A New Method for Determining Urine Frequency in Rats
Combinatorial Pharmacology in Mice: Integration of Brain Microdialysis and Automated Blood Collection in a Single Subject
Demonstration of the relationship between in vivo dopamine efflux, behaviour and drug pharmacokinetics
Oral and Intravenous Dosing in Combination with Automated Blood Sampling for a Complete Bioavailability Profile in Mice
Peritoneal Microdialysis with Simultaneous Venous Blood Sampling: Insights into Pharmacokinetics of Free vs. Total Drug in
Rodents
Programmed Blood and Bile Collections from Freely-Moving Rats: A Study Tracking Nicotine and its Cotinine Metabolite
Discovery Rat Pharmacokinetic Applications Using the Culex Automated Blood Sampler
Use of the Culex Bambino to Measure Brain Neurotransmitters, Plasma Corticosterone and Drug Levels with Behaviour in the
Same Freely-Moving Rat
Automated Dosing and Sampling System Coupled to LC/MS/MS for the Determination of Endogenous Steroids and DMPK Study
Can Preclinical ADMET-PK Now Be Done More Efficiently and Effectively?
Online Monitoring of Hydrogen Peroxide in Freely-Moving Rodents
Automating Oral Dosing for PK/PD Applications
Continuous Monitoring of Corticosterone in Conscious and Freely-Moving Rats for Anxiolytic Drug Screening
Monitoring Free Drug in Lung Tissue with Concurrent Automated Blood Sampling in the Unrestrained Rat
Use of Behavior as a Pharmacodynamic Parameter During Pharmacokinetics Studies on an Automated Blood Sampler
Evaluation of Post-Surgical Recovery for Rats in an Automated Blood Sampler vs. Rats Returned to a Home Cage
Automated Blood Sampling with Concurrent Electrocardiograms for Laboratory Animals
Influence of Blood Sampling Method on Biometric and Chemical Markers of Stress in the Rat
An Automated Blood Sampler for Pharmacokinetic and Pharmacodynamic Studies
Automated Blood Sampling From Awake Laboratory Animals Coupled to 96-Well Sample Preparation Tools and LC/MSMS Improves
Data Quality, Enhances Efficiency and Facilitates Parallel Measurements of Behavior and Physiological Parameters
Monitoring Animal Activity during Automated Blood Sampling: An Early Warning System During First-Pass in Animal Drug
Screening
Effects of Blood Sampling Technique on Pharmacokinetics
Experiences with Automated Blood Sampling from Freely Moving Rats for PK/PD Screening
BioTrap Sample Extraction Column: A New Approach for On-Line Sample Presentation in Drug Metabolism Studies
Preclinical
Contact BASi for access to a PDF of any of the following titles:
LC/H-ESI MS/MS and Higher Mass Resolution for Quantitative Assay and PK and PD Study Using Automated Blood Sampling Systems
Elimination Of Interanimal Differences By Using A Single Mouse For The Entire PK/PD Study
Continuous Collection of Saliva from an Untethered Human: Implications for Pharmacokinetics and Pharmacodynamics
Absorption Characteristics of an Isolated Segment of Jejunum in a Monkey
Investigation of In Vitro Metabolism of Silibinin in Liver Microsomes and Cytochrome P450 Isozyme Identification
Rapid Quantitative Determination Of Multiple Cytochrome P450 Probe Substrates by Gradient Liquid
Chromatography/Electrospray Ionization-Ion Trap Mass Spectrometry
Evaluation of Rats for a New In Vivo Screening Model of Q-T Interval Prolongation by New Chemical Entities
Ultrafiltration Sampling in the Rodent Workstation™ to Study the Metabolic Effects of Green Tea on Zucker Diabetic Rats
Effect of Acute Administration of Hypericum Perforatum Extract on Dopamine Release in the Rat Brain
Application of Microdialysis to In Vitro Metabolism Studies
Electrochemistry
Glucose Test Strips and Electroanalytical Chemistry in the Undergraduate Laboratory
Jonathon O. Howell, Bioanalytical Systems Inc., West Lafayette, IN 47906
Peter T. Kissinger, Department of Chemistry, Purdue University, West Lafayette, IN 47907
Arlen D. Kaufman and Hsiang-Jui Yeh, Department of Chemistry, University of Evansville, 1800 Lincoln Avenue, Evansville, IN
47722
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