BASi In Vivo Newsletter - February 2010

Culex® In Vivo 1-Day Workshops

• Surgery Demonstrations
  • Mouse Cannulation
  • Portal Cannulation
  • Femoral Artery Cannulation
• Product Demonstrations
  • NEW Culex ABC unit
  • Automated Dosing
  • Automated Blood Sampling
  • Single-station Culex Cart
  • Large-volume Fraction Collector
  • Empis Infusion System

Boston, MA
Friday March 12
9:00 am to 4:00 pm
Breakfast and lunch provided 

Space is limited, so sign up early! Contact Natasha Nikolaidis, Product Manager, email

Barcelona, Spain
Friday March 19
9:00 to 17:00
Breakfast and lunch provided 

For additional information or to sign up, contact Emily Chinn, Business Development Manager, email

Upcoming Events

Society of Toxicology (SOT) Meeting in Salt Lake City, Utah - March 8-10. Visit Candace Rohde Johnson and the BASi CRO team at booth no. 1416. Check out the new Culex-L ABC sampling unit for large animal models (including primates). See below to find out more about the Culex-L.

Experimental Biology Meeting in Anaheim, California - April 24-28. Stop by booth no. 231 to find out about all of the products that BASi offers for your in vivo studies.

New Developments

BASi is proud to offer two new products in the Culex® family -- the Culex ABC and the Culex-L ABC. The ABC (Automated Blood Collection) systems are ideal for researchers with an interest in blood collection only. However, if you wish to expand your approach at a later time, the ABC units can be fully integrated into the standard Culex system.

These systems offer the same reliability that you've come to appreciate in the Culex line of products, but offer additional flexibility for those with limited space, limited budgets, or a large variety of animal models.

Culex ABC Applications: High Throughput Rodent Pharmacokinetic Studies

The Culex system has always set a high standard for automated blood sampling by allowing researchers to collect accurate and undiluted blood samples. The Culex ABC continues this tradition, but has some added benefits that make it an attractive alternative to the original system.

For researchers that are only interested in blood collection, a swivel-based system can be extremely useful. The swivel-based ABC permits connection to a wide variety of catheters, swivels and connectors. This flexibility also makes it easier to sample from a multitude of species (rats, guinea pigs, hamsters, etc).

In addition, the animal can be kept in his home cage for the duration of sampling, reducing acclimation periods and allowing you to perform more studies during the week. The small footprint of this system (32in h x 16in w x 19in d [~81cm x 41cm x 48cm]) makes it easy to fill your limited lab space with multiple machines. The combination of flexible connections, limited acclimation times, and space savings can quickly transform your lab into a high throughput lab, churning out robust data from stress-free subjects.

Culex-L ABC Applications: Primate Blood Sampling

Traditional methods for sampling from primates require restraint of the subject through mechanical or chemical means. In addition, long term sampling requires multiple needle sticks making the procedure stressful and dangerous for both the animal and the technician.

With a combination of the right supplies, it is now possible to automate the blood collection process from a freely moving primate. Because of the flexibility of the Culex-L ABC , you are not restricted to primate collection. In fact, the system allows for multiple blood collections ranging in size from 50uL to 1.75mL per timepoint, and a range of species that could include swine, canines, or any other subject that has been implanted with a catheter or VAP. This approach to blood collection insures stress reduction and thereby improves the quality of the data that is collected.

For More Information

To learn more about any of the products and services mentioned in this newsletter, contact us at 800.845.4246:
Natasha Nikolaidis Ext. 815 or email
Candace Rohde Ext. 394 or email