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In 1803 Dalton speculated that all atoms of a given element are identical in size and mass and that the relative masses of atoms of different elements can be deduced by an assumed microscopic atom-ratio coupled with macroscopic chemical analysis. In so doing he explained the Law of Constant Composition and rationalized the emerging Law of Multiple Proportions. When in 1808 his ideas were widely circulated in his text A New System of Chemical Philosophy they were met with a mixed reception. Wollaston, Thomson, and Berzelius were (initially at least) enthusiastic converts, while Berthollet and Gay-Lussac were skeptical. For the remainder of his long life, Dalton never wavered in his belief in the literal existence of elementally identical microscopic atoms and fixed-atom ratios, but his contemporaries were less sure and at times disbelieving. It was to be more than fifty years, long after Daltons death, before his ideas finally won universal acceptance from chemists. Physicists took a little longer. During his last 30 years Dalton was decreasingly productive and increasingly celebrated. His elaborate funeral in 1844 proved an embarrassment to his devout Quaker friends. References Gay-Lussac | Berzelius | Wöhler | Dumas | Graham | Bunsen | Hofmann Bioanalytical Systems, Inc. |