Xenobiotic Metabolism
An examination of the fate of foreign compounds (xenobiotics) in biological systems is a natural outgrowth of man’s curiosity about his environment, and his susceptibility to it. While most modern studies concern the fate of drugs in man and animals, there are also investigations into the fate of organic compounds in plants, fruit flies, nematodes and easts. The term “xenobiotic” was coined to cover all compounds that are “foreign” to the organism under study. In some situations, this is loosely defined to include naturally present compounds administered by alternate routes or at “unnatural” concentrations.
This historical calendar, a joint project of Bioanalytical Systems, Inc. (BAS) and the International Society for the Study of Xenobiotics (ISSX), portrays some of the pioneering studies in xenobiotic metabolism during the past two centuries. There is much more science behind these stories, and this will be posted on the ISSX web site at www.issx.org. The information presented in this calendar is posted on the BAS web site (along with past historical calendars on chemistry, electrochemistry and pharmaceutical companies) at www.bioanalytical.com.
Index |
Intro | The Beginning | Oxidation
Sulfation | Glucuronides
| Acetylation, Methylation
Reduction | Mercapturic
Acid | Founding of the Field
Drug Metabolism Methodology | In
Vitro Technology | P-450
The Future